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KMID : 1084220160230030187
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Journal of Rheumatic Diseases
2016 Volume.23 No. 3 p.187 ~ p.192
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A Case of Sarcoidosis That Improved upon Discontinuation of Etanercept
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Kang Ji-Hyoun
Ahn Joon-Ho
Yu Ji-Eun
Kim Ji-Eun
Yim Yi-Rang
Lee Jeong-Won
Lee Kyung-Eun
Park Dong-Jin
Wen Li-hui
Park Yong-Wook
Lee Shin-Seok
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Abstract
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31-year-old man who had been prescribed etanercept over a 3-year period for treatment of ankylosing spondylitis presented with newly developed dry cough, chills, myalgia, and weight loss. Chest computed tomography showed multiple reticulonodular pulmonary infiltrates and bilateral mediastinal, hilar, and peribronchial lymphadenopathy. Biopsy of a paratracheal lymph node revealed chronic granulomatous inflammation without necrosis, and the serum angiotensin-converting enzyme level was elevated. Sarcoidosis was diagnosed. His laboratory and radiological findings, and clinical symptoms improved only after discontinuation of etanercept without treatment. Although etanercept-induced sarcoidosis is rare, this case report suggests that sarcoidosis should be considered in the differential diagnosis of patients treated with the tumor necrosis factor inhibitor.
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KEYWORD
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Etanercept, Sarcoidosis, Ankylosing spondylitis
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